Mounting evidence supports the use of ketogenic diets for bipolar disorder because of the ketogenic diet's ability to modify underlying pathological mechanisms such as brain hypometabolism, neurotransmitter imbalances, brain inflammation, and oxidative stress. There are numerous anecdotal reports, published case studies in peer-reviewed journals, articles reviewing the literature on the topic, and randomized controlled trials being conducted evaluating the ketogenic diet as a treatment for bipolar disorder.